The experimental results show that the fear memory time of the VD model group mice is shortened, and the neurons in the hippocampus CA 1 area of ​​the brain are damaged, and the holly moss extract can significantly increase the fear memory time of the VD mice and reduce the neuronal cell damage of the VD mice Combined with its influence on the apoptotic proteins Bcl -2 and Bax, it can be inferred that Mao Dongqing exerts a neuroprotective effect by inhibiting the apoptosis of hippocampal CA1 area.1 Pole-climbing experiment on the 30th day 2h after the administration, the pole-climbing experiment was tested. The scene is the same as the scene in the training stage.

10 Statistical processing method SPSS 17. 1 Materials and methods 1.09, indicating that the VD model was successfully replicated and the memory ability of the mice was reduced. The hippocampus is related to brain memory and is sensitive to Cio7 for cerebral ischemia. by

Department of Centrifuge tube Rack Manufacturers Identification, Guangzhou University of Chinese Medicine. After the perfusion was completed, the brain tissue was taken and fixed in 10% neutral formalin solution for pathological section preparation. The rod climbing experiment was used to evaluate the differences in the coordination ability of mice between each group. A total of 4 cycles with an interval of 15 s each.2 The effect of PHRE on the conditioned fear memory of mice.5 cm was fixed on the foam box, and the bamboo pole was wrapped with gauze to prevent slipping Place the mouse head down on the top of the bamboo pole, and record the time it takes for the mouse to climb the full length of the pole.3 Instrument AUM 220D electronic analytical balance, Japan Shin ad zu company ;Ultra-low temperature refrigerator, American Thermo company;

Ice maker, Japanese Sanyo company product; High-speed refrigerated centrifuge, China Zhongke Zhongjia Science and Technology Instrument Co. Impairment, memory impairment; Compared with the model group, Ilex glabra extract can increase the expression of Bcl -2 and reduce the expression of B ax, thereby significantly increasing the ratio of Bc}2 to ax and causing the apoptosis of hippocampal CA1 cells inhibition. Keywords: Ilex extract; Vascular dementia; Learning and memory ability

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